Guillain-Barre syndrome is also called acute inflammatory demyelinating polyneuropathy. Which statement best describes its typical progression?

• A. Slow, progressive weakness limited to the upper limbs
• B. Primary cognitive decline without motor signs
• C. Rapid onset of ascending weakness and paralysis starting at the lower extremities
• D. Seizures

Answer: (C)

Guillain-Barré syndrome is an acute autoimmune neuropathy that causes rapid, ascending motor weakness. The hallmark progression is a quick onset of weakness that begins in the legs and moves upward toward the trunk and arms, and it can progress to involve respiratory muscles. This contrasts with slow, one-sided, or upper-limb–restricted weakness and with cognitive changes or seizures, which are not typical features of this condition.